Phentermine, similar to an amphetamine, boosts the central nervous system, raising heart rate, lowering appetite, and is used with diet and exercise to address obesity, particularly in individuals with risk factors like high blood pressure, high cholesterol, or diabetes. Other uses may exist.

Metformin, primarily prescribed for managing type 2 diabetes, but also helps with weight loss in several ways:

Metformin can lead to a decrease in appetite, aiding individuals in consuming fewer calories. It enhances insulin sensitivity, helping the body use insulin more effectively. This can lead to better glucose control and reduced fat storage. By stabilizing blood sugar levels, Metformin may reduce the likelihood of insulin spikes that can contribute to weight gain. Metformin may also enhance calorie burning, promoting weight loss.

Topiramate, originally an antiepileptic drug, has been prescribed off-label for weight loss. Its potential mechanisms for aiding weight loss include:

1. Appetite Suppression: Topiramate may reduce appetite, leading to lower calorie intake.

2. Increased Satiety: It might enhance the feeling of fullness, promoting reduced food consumption.

Clinical trials have confirmed that individuals using topiramate over an extended duration witnessed a noteworthy decrease in body weight. Specifically, one study indicated a 7% reduction in baseline body weight after 60 weeks of treatment.

Bupropion, an antidepressant with appetite-suppressing effects, and naltrexone, typically administered for addiction issues, can also reduce hunger and food cravings.

Combined as Contrave, they are prescribed to assist obese or overweight adults with weight-related health concerns, in conjunction with diet and exercise. However, Contrave does not address conditions like high blood pressure, diabetes, or high cholesterol.

Importantly, Contrave is not approved for treating depression, psychiatric conditions, or aiding smoking cessation

A compound medication blend (Bupropion HCl / Phentermine HCl / Topiramate / Naltrexone HCl / Methylcobalamin) (Slow Release) aimed to decrease appetite, increase metabolism, control cravings, and boost energy.

A medication primarily indicated for the management of type 2 diabetes. It contains the active ingredient semaglutide and is designed to improve blood sugar control in individuals with diabetes. Typically prescribed in lower doses, Ozempic helps regulate glucose levels and is an effective tool in the comprehensive treatment of diabetes.

A medication containing semaglutide as its active ingredient, serves a distinct purpose as a medication approved for chronic weight management. Specifically designed for adults with a body mass index (BMI) of 30 kg/m² or greater, or for those with a BMI of 27 kg/m² or greater and at least one weight-related condition, Wegovy is administered in higher doses to facilitate weight loss. Unlike Ozempic, Wegovy is not primarily intended for diabetes management but focuses on addressing obesity and related health concerns.

A natural supplement derived from the bark of the Pausinystalia yohimbe tree. It contains yohimbine and is often marketed for potential benefits in weight loss and sexual performance.